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一.抗癫痫药物的致畸性癫痫妇女妊娠期服用抗癫痫药物对胎儿的致畸性问题已广为人们所关注。自从1963年 Mulier—kupper 看到一例24岁用甲妥因治疗的病人生了一个畸形婴儿以后,类似的报告不断出现。有作者综述了32篇文献统计,服抗癫痫药的孕妇生的4199个婴儿中有321个畸形婴儿,发生率为7.64%。没有服用抗癫痫药的癫痫孕妇生的945个婴儿中有40个是畸形,畸形发生率为4.23%。二者在统计学上有显著性差异。服用癫痫药的孕妇生的婴儿各类畸形发生率比普通人群畸形发生率高2～3倍。动物实验证实抗癫痫药物有致畸作用,给妊娠期的小白鼠服用苯妥因钠、鲁米那、朴痫酮、三甲双酮、丙戊酸钠等,其所生小白鼠中畸形率明显增高。
One. Teratogenic drugs antiepileptic epilepsy Pregnant women taking antiepileptic drugs teratogenicity of the fetus has been widely concern. Similar reports have been reported since Mulier-Kupper saw a 24-year-old patient who had been treated with Metoprolol a deformed baby in 1963. Some authors review the 32 articles statistics, the fetus of 4199 infants taking antiepileptic drugs in pregnant women, there are 321 deformities infants, the incidence was 7.64%. 40 out of 945 babies born to epileptic pregnant women who did not take antiepileptic drugs had a deformity of 4.23%. There was a statistically significant difference between the two. Pregnant women taking epilepsy drugs of various types of deformity incidence of malformations than the average population of 2 to 3 times higher. Animal experiments confirmed that antiepileptic drugs have teratogenic effects, to take gestational mice taking phenytoin sodium, luminal, PGE, trimethoprim, sodium valproate, the mice born born deformity was significantly higher .