Myosin specific-T lymphocytes might mediate myocardial inflammation and remodeling after AMI. Myosin- activated or unactivated T lymphocytes in vitro were transferred into na?ve syngeneic rats, respectively. T lymphocyte infiltration and myocyte apoptosis were explored by the H&E and TUNNEL. Proteins and mRNA levels of cytokines (IL-1β, IL-6 and TNF-α) in myocardium were determined by RT-PCR and immunohisto- chemistry. T lymphocyte infiltration was evidently observed after one week of activated T cell transfer. The expressions of cytokines were elevated markedly one week later. The myocyte apoptosis occurred after T lymphocyte infiltration in myocardium. Our findings suggest that cardiac myosin activated-T lymphocytes may mediate myocardial inflammation and remodeling. Myosin specific-T lymphocytes may mediate myocardial inflammation and remodeling after AMI. Myosin-activated or unactivated T lymphocytes in vitro were transferred into na? Ve syngeneic rats, respectively. T lymphocyte infiltration and myocyte apoptosis were explored by the H & E and TUNNEL. Proteins and The levels of cytokines (IL-1β, IL-6 and TNF-α) in myocardium were determined by RT-PCR and immunohisto- chemistry. T lymphocyte infiltration was evidently observed after one week of activated T cell transfer. The expressions of cytokines were Our marked suggests that cardiac myosin activated-T lymphocytes may mediate myocardial inflammation and remodeling.