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本实验研究膜抗原（Ｌｉｐｏｓｔｎ）对人胃腺癌ＬＡＫ增殖及杀伤活性的影响作用。患者胃肠道肿瘤相关抗原免疫电泳检测阳性。结果表明，Ｌｉｐｏｓｔｎ对ＬＡＫ增殖有促进作用，以２．５μｇ剂量最为显著（与对照比较，Ｐ＜０．００１）。同时，Ｌｉｐｏｓｔｎ与ｒＩＬ－２共激活的ＬＡＫ细胞体外杀瘤活性得到增强，杀伤率近似或超过效／靶比增加１倍时的ＬＡＫ杀伤率。提示该膜抗原增强了胃腺癌ＬＡＫ杀瘤活性，具有使过继免疫治疗不敏感群体（胃癌等）受益的潜在价值。
This study investigated the effect of membrane antigen (Lipostn) on the proliferation and killing activity of LAK in human gastric adenocarcinoma. The patient’s gastrointestinal tumor-associated antigen was positive by immunoelectrophoresis. The results showed that Lipostn promoted proliferation of LAK, with the dose being the most significant at 2.5 μg (P<0.001 compared with control). At the same time, the killing activity of LAK cells co-activated by Lipostn and rIL-2 was enhanced in vitro. The killing rate was similar to or exceeded the LAK kill rate when the effect/target ratio was increased by 1 time. It is suggested that the membrane antigen enhances the LAK tumoricidal activity of gastric adenocarcinoma and has the potential value of benefiting adoptive immunotherapy-insensitive populations (gastric cancer, etc.).