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以0、200×10-6、500×10-6、1000×10-6含铅饮用水染毒大鼠，在4、8、12周分批处死动物，取血、尿及组织分别测定铅、锌、钙等元素。结果表明，染毒200×10－6动物在4周时即出现全身症状；血铅浓度随染毒剂量增加而增高；尿铅、锌、钙的排出三者呈平行关系，排出高峰在4周。高尿锌导致脑、睾丸、骨、胰腺等组织锌含量降低，说明锌在铅中毒的发生机制中起重要作用，实验为应用锌制剂预防和治疗铅中毒提供依据。高尿钙所致机体影响有待进一步研究。
The rats were exposed to 0,200 × 10-6,500 × 10-6,1000 × 10-6 lead drinking water. Animals were sacrificed in batches at 4,8,12 weeks. Blood, urine and tissues were collected for determination of lead , Zinc, calcium and other elements. The results showed that systemic symptoms of 200 × 10-6 animals were observed at 4 weeks. Blood lead levels increased with the increase of exposure dose. Excretion of lead, zinc and calcium in urine showed a parallel relationship with a peak of 4 weeks . High urinary zinc lead to reduced zinc content in brain, testis, bone, pancreas and other tissues, indicating that zinc plays an important role in the pathogenesis of lead poisoning. The experiment provides the basis for the prevention and treatment of lead poisoning by zinc preparations. The impact of high urinary calcium body needs further study.