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目的研究并分析丙戊酸联合拉莫三嗪治疗各型癫痫的疗效及安全性。方法我院2010年11月1日～2012年12月1日期间共收治了120例癫痫患者,将其进行随机分组,即对照组的60例癫痫患者的临床治疗药物为丙戊酸,而观察组60例癫痫患者的临床治疗药物为丙戊酸联合拉莫三嗪,对比上述两组患者的临床治疗有效性与安全性。结果观察组患者的临床治疗总有效率为95%,不良反应发生率为1.67%,与对照组患者的86.67%和8.33%相比,差异具有显著(P<0.05)。结论对于各类癫痫患者而言,运用丙戊酸联合拉莫三嗪的方法进行治疗十分安全,不良反应发生率低,且临床疗效显著,值得推广。
Objective To study and analyze the efficacy and safety of valproic acid plus lamotrigine in the treatment of various types of epilepsy. Methods A total of 120 patients with epilepsy were enrolled from November 1, 2010 to December 1, 2012 in our hospital. Patients in the control group were treated with valproic acid in 60 patients with epilepsy. Group 60 patients with epilepsy in clinical treatment of valproic acid combined with lamotrigine, compared to the above two groups of patients with clinical efficacy and safety. Results The total effective rate of clinical treatment in the observation group was 95% and the incidence of adverse reactions was 1.67%. The difference was significant (P <0.05) compared with 86.67% and 8.33% in the control group. Conclusion For all kinds of patients with epilepsy, the combination of valproic acid and lamotrigine is safe and the incidence of adverse reactions is low. The clinical efficacy is significant and worthy of promotion.