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目的 探讨阴囊Paget病的诊断、治疗及预后。方法 对我院自1986年9月至1994年9月收治的17例病人,术前取活检经病理证实为阴囊Paget病后施行手术,术后化疗、放疗。结果 浸润程度浅、无淋巴转移者,5年生存率为100％,10年生存率为76.9％。浸润程度深,有淋巴转移者,5年生存率为25％,10年无存活。结论 阴囊Paget病的治疗以手术为主,在未穿透基底膜、淋巴转移前施行手术,预后良好。临床上早期很易误诊为湿疹、皮炎、股癣等,故早期做出正确诊断、早期手术是影响预后的关键。
Objective To investigate the diagnosis, treatment and prognosis of scrotal Paget disease. Methods For the 17 patients who were admitted to our hospital from September 1986 to September 1994, preoperative biopsy was performed after pathological diagnosis of Paget’s disease in the scrotum, followed by surgery, postoperative chemotherapy, and radiotherapy. Results In patients with minimal invasion and no lymph node metastasis, the 5-year survival rate was 100%, and the 10-year survival rate was 76.9%. Deep infiltration, lymph node metastasis, 5-year survival rate was 25%, no survival for 10 years. Conclusion The treatment of Paget’s disease in the scrotum is mainly surgery. The surgery is performed without permeating the basement membrane and lymphatic metastasis. The prognosis is good. Early clinically, it is easy to be misdiagnosed as eczema, dermatitis, and tinea cruris. Early diagnosis and early surgery are the key factors affecting the prognosis.