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恶性疟疾的肝功能已有许多研究,但间日疟中肝功能研究却很少引起注意。本文对80名1个月至3岁患间日疟的小儿,在急性发作期和抗疟治疗6周以后进行了肝功能研究。观察到血清中SGOT、SGPT、硷性磷酸酶分别有68%、39%、40%的病例增高。SGOT水平比SGPT高些,而这两种酶在肝肿大病例中更高。肝功能障碍是暂时性的,因为接受治疗6周以后这些酶都恢复了正常。肝功能暂时性的紊乱在儿童疟疾中是一个常见的特征。肝功能在疟疾发作终止时可得到恢复,但在长期持续的、轻度的疟疾感染可引起持续性的肝脏损害。
Many studies have been conducted on the liver function of falciparum malaria, but studies of liver function in P. vivax seldom draw much attention. In this paper, 80 children aged 1 month to 3 years old suffering from vivax malaria in the acute attack and anti-malarial treatment for 6 weeks after the liver function study. Serum SGOT, SGPT, alkaline phosphatase were observed in 68%, 39%, 40% of the cases were increased. SGOT levels higher than SGPT, and these two enzymes in hepatomegaly cases higher. Liver dysfunction is temporary, as these enzymes have returned to normal after 6 weeks of treatment. Temporary disorders of liver function are a common feature in childhood malaria. Liver function can be recovered at the end of a malaria episode, but persistent, mild malaria infection can cause persistent liver damage in the long term.