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[目的]观察补脾益气活血汤联合二甲双胍治疗2型糖尿病疗效。[方法]使用随机平行对照方法,将80例住院及门诊患者按病志号抽签简单随机分为两组。基础治疗:健康教育,正确认识和对待糖尿病,保持心情舒畅,建立正常生活方式,戒烟和烈性酒,配合医生进行合理的治疗和监测;制定医学营养方案,控制饮食,以素食为主,其他为辅,营养均衡;体育锻炼,有规律合适运动,循序渐进、量力而行、动中有静、劳逸结合。对照组二甲双胍片,0.5g/次,2次/d;随治疗需要,可每周增加0.5g,逐渐加至2g/d。治疗组补脾益气活血汤(山药30g,黄芪20g,知母15g,鸡内金5g,葛根、五味子各10g,天花粉、丹参、当归、三七各5g),1剂/d,煎药室统一煎煮,100mL/次,3次/d;二甲双胍治疗同对照组。连续治疗4周(28d)为1疗程。观测临床症状、空腹血糖、糖负荷后2h血糖、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效24例,有效14例,无效2例,总有效率95.00%。对照组显效16例,有效20例,无效4例,总有效率90.00%。两组临床疗效无显著差异(P>0.05)。血糖、餐后血糖、糖化血红蛋白、空腹胰岛素两组均有改善(P<0.01),餐后血糖、糖化血红蛋白、空腹胰岛素治疗组改善优于对照组(P<0.01),血糖改善两组间无明显差异(P>0.05)。[结论]补脾益气活血汤联合二甲双胍治疗2型糖尿病,疗效满意,无副作用,值得推广。
[Objective] To observe the curative effect of Bupi Yiqi Huoxue Decoction combined with metformin on type 2 diabetes mellitus. [Methods] Using randomized parallel control method, 80 inpatients and outpatients were randomly divided into two groups according to their random numbers. Basic treatment: health education, correct understanding and treatment of diabetes, maintain a comfortable mood, establish a normal lifestyle, quit smoking and spirits, cooperate with the doctor for reasonable treatment and monitoring; formulate medical nutrition plan, control diet, mainly vegetarian, others are Auxiliary, nutritionally balanced; physical exercise, regular and appropriate exercise, step by step, according to what they do, moving in static, work and rest. The control group metformin tablets, 0.5g / time, 2 times / d; with treatment needs, weekly increase 0.5g, gradually increased to 2g / d. The treatment group was treated by tonifying the spleen and invigorating qi and activating blood circulation soup (30g of yam, 20g of Astragalus, 15g of Anemarrhena asphodeloides, 5g of chickweed gold, 10g of Pueraria, Schisandra each, TCS, Salvia miltiorrhiza, Angelica, Uniform decoction, 100mL / time, 3 times / d; metformin treatment with the control group. Continuous treatment for 4 weeks (28d) for a course of treatment. Clinical symptoms, fasting blood glucose, blood sugar 2h after glucose loading, HbA1c, FINS and adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Result] The treatment group was effective in 24 cases, effective in 14 cases, invalid in 2 cases, the total effective rate was 95.00%. In the control group, 16 cases were markedly effective, 20 cases were effective, 4 cases were ineffective, and the total effective rate was 90.00%. There was no significant difference between the two groups (P> 0.05). Blood sugar, postprandial blood glucose, glycosylated hemoglobin and fasting insulin were improved in both groups (P <0.01). The improvement of postprandial blood glucose, glycosylated hemoglobin and fasting insulin group was better than that of the control group (P <0.01) Significant difference (P> 0.05). [Conclusion] Bupi Yiqi Huoxue Decoction combined with metformin in type 2 diabetes mellitus has satisfactory curative effect and no side effects and is worth promoting.