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目的 评价胸腺切除治疗重症肌无力的疗效及影响因素。方法 对我院行胸腺切除治疗重症肌无力的 96例患者随访 2年以上。疗效评价按Monden提出的标准 ,分为缓解、改善、无效和恶化。对年龄、性别、血浆乙酰胆碱受体 (AchR)抗体效价、病程、病理类型、临床分型、手术方式等因素进行统计分析。结果 本组 96例中 ,缓解 2 9例 (30 .2 % ) ,改善 4 2例 (4 3.8% ) ,无效 1 9例 (1 9.8% ) ,恶化 6例 (6 .2 % ) ,有效率 74 % (71 / 96 )。病程 >2年与≤ 2年的疗效比较有显著性差异 (P <0 .0 5 ) ;性别、年龄、血浆乙酰胆碱受体 (AchR)抗体效价、病理、临床分型、手术方式均与疗效无关。结论 重症肌无力一旦确诊 ,尽早行胸腺切除术 ,可取得满意疗效
Objective To evaluate the efficacy and influencing factors of thymectomy in the treatment of myasthenia gravis. Methods 96 cases of myasthenia gravis in our hospital were followed up for more than 2 years. Efficacy evaluation according to Monden’s criteria, divided into mitigation, improvement, ineffectiveness and deterioration. Age, sex, plasma AchR antibody titer, duration of disease, pathological type, clinical classification, surgical methods and other factors were statistically analyzed. Results Ninety-six cases (30.2%) were alleviated, 42 cases (48%) were improved, 19 cases (9.8%) were ineffective, and 6 cases (6.2%) were ineffective. The effective rate 74% (71/96). Duration of disease> 2 years and ≤ 2 years, there was significant difference (P <0 05); sex, age, plasma AchR antibody titer, pathology, clinical classification, surgical methods and efficacy Nothing to do Conclusion Myasthenia gravis once diagnosed, as soon as possible underwent thymectomy, can obtain satisfactory results