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目的：探讨风湿性心脏病（风心病）心功能不全时红细胞免疫状态。 方法：将９８例患者按心功能（ＮＹＨＡ）分级分为轻度心力衰竭（心衰）组３６ 例、中度心衰组３３ 例及重度心衰组２９例，另有健康对照组４８ 例，检测其红细胞受体花环率、红细胞免疫复合物花环率及红细胞免疫增强因子、红细胞免疫抑制因子、过氧化脂质的变化。 结果：心衰患者红细胞受体花环率、红细胞免疫复合物花环率和红细胞免疫增强因子均显著下降（Ｐ＜ ０．０１），而红细胞免疫抑制因子、过氧化脂质则明显升高（Ｐ＜ ０．０１），其变化且随心衰程度加重而更加显著。相关分析表明：红细胞受体花环率与红细胞免疫增强因子呈显著正相关（ｒ＝ ０．９２，Ｐ＜ ０．０１），与红细胞免疫抑制因子、过氧化脂质呈显著负相关（ｒ＝ － ０．８７、－ ０．８１，Ｐ＜ ０．０１）。 结论：提示风心病心功能不全时存在红细胞免疫功能下降，且与红细胞免疫调节因子改变及过氧化脂质增加有关
Objective: To investigate the immune status of erythrocytes in patients with rheumatic heart disease (rheumatic heart disease) with cardiac insufficiency. Methods: Ninety-nine patients with mild heart failure (CHF), 33 patients with moderate heart failure (HF) and 29 patients with severe heart failure (HF) were divided into three groups according to NYHA classification: 48 patients, The rosette rate of erythrocyte receptor, rosette rate of erythrocyte immune complex, erythrocyte immune enhancement factor, erythrocyte immunosuppressive factor and lipid peroxidation were detected. Results: The levels of erythrocyte receptor rosette, erythrocyte immune complex rosette and erythrocyte immune enhancement factor (P <0.01) were significantly decreased in patients with heart failure, while erythrocyte immunosuppressive factor and lipid peroxidation were significantly increased (P < 0.01), its change and worsened with the degree of heart failure and more significant. Correlation analysis showed that there was a significant positive correlation between erythrocyte receptor rosette rate and erythrocyte immune enhancement factor (r = 0.92, P <0.01), negative correlation with erythrocyte immunosuppressive factor and lipid peroxidation (r = - 0.87, -0.81, P <0.01). Conclusion: There is a decrease of erythrocyte immune function in patients with rheumatic heart failure, which is related to the change of erythrocyte immunoregulatory factor and the increase of lipid peroxidation