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目的：探讨胶体金免疫层析法(GICA)和酶联免疫法(ELISA)用于手足口病早期患儿抗EV-71-IGM抗体检测临床价值差异。方法选取我院近期收治手足口病早期患儿共180例，依次行胶体金免疫层析法(GICA)和酶联免疫法(ELISA)进行抗EV-71-IGM抗体检测，比较两种方法检测手足口病早期患儿抗EV-71-IGM抗体阳性率及临床诊断一致性。结果 GICA和ELISA用于手足口病早期患者抗EV-71-IGM抗体检测符合率为76.67%（138/180），临床诊断一致性检测Kappa值=0.52；GICA和ELISA用于手足口病早期患者抗EV-71-IGM抗体检测阳性率分别为47.78%（86/180），26.67%（48/180）；GICA法用于手足口病早期患者抗EV-71-IGM抗体检测阳性率显著高于ELISA法，差异有统计学意义（<0.05）。结论相较于ELISA法，GICA用于手足口病早期患儿抗EV-71-IGM抗体检测阳性率更高，且对于两种方法均检测阴性患儿，应及时复查避免漏检。“,”Objective To investigate clinical value dif erences of two kinds of detected methods for detection on anti EV-71-IGM antibody of children with early stage of foot and mouth disease including col oidal gold immunochromatography assay (GICA) and enzyme linked immunosorbent assay (ELISA). Methods 180 cases of children with early stage of foot and mouth disease were chosen in recent year in our hospital and detected anti EV-71-IGM antibody by col oidal gold immunochromatography assay (GICA) and enzyme linked immunosorbent assay (ELISA); and the positive detection rate and clinical diagnosis consistency of two kinds of detected methods for detection on anti EV-71-IGM antibody of children with early stage of foot and mouth disease was compared. Results The detected coincidence rate of two kinds of detected methods for detection on anti EV-71-IGM antibody of children with early stage of foot and mouth disease including GICA and ELISA was 76.67%(138/180)and Kappa value of clinical diagnosis consistency was 0.52. The positive detection rate of two kinds of detected methods for detection on anti EV-71-IGM antibody of children with early stage of foot and mouth disease including GICA and ELISA were separately 47.78%(86/180), 26.67%(48/180);the positive detection rate of two kinds of detected methods for detection on anti EV-71-IGM antibody of children with early stage of foot and mouth disease by GICA was significantly higher than ELISA( <0.05). Conclusion Compared with ELISA method, GICA method for detection on anti EV-71-IGM antibody of children with early stage of foot and mouth disease possess higher positive detection rate; and for children with negative detection results by two kinds of methods, it should be promptly review in order to avoid missing detection.