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近十几年来,药物缓释制剂,尤其是控制释放体系有较快发展,受到国内外的重视。其优点是可以做到接近恒速释放药物,不仅能避免血药浓度上下波动,而且还能延长药效,且其有效性和安全性都比传统的剂型优越。下面介绍几个主要给药途径的控释体系(亦可通称控释制剂)。 一、口服控释给药体系 发展较早的是Alza药厂的渗透泵片(OROS),为一种微小的初级渗透泵结构,形状与普通片剂无异。先将固体药物加赋形剂制成片心,外面包一层
In recent ten years, the drug sustained-release preparation, especially the controlled release system, has developed rapidly, and has drawn great attention both at home and abroad. The advantage is that the drug can be released at a constant speed, which can not only avoid fluctuation of plasma concentration but also prolong the efficacy of the medicine, and the efficacy and safety of the medicine are superior to the traditional dosage forms. Here are some of the main route of administration of the controlled release system (also known as controlled release formulations). First, the oral controlled release drug delivery system is developed earlier Alza pharmaceutical osmotic pump (OROS), a tiny primary osmotic pump structure, the shape is no different from ordinary tablets. The first solid drug plus excipients made into tablets heart, the outer package