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Extracellular microvesicles (MVs) and exosomes (EXs) are the major types of extracellular vesicles (EVs) which can carry and transfer molecular messages (proteins,mRNAs and microR-NAs,etc)[1].Thereby,EVs could serve to mark the changes of the producing cells and to function on the recipient cells[2].These features deem EVs as potential biomarkers and pharmacological targets for various diseases including metabolic,vascular and neurological diseases and tumors[3].The current special feature provides reviews and original research articles on novel pharmacological studies of MVs and EXs.