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视网膜色素上皮细胞（RPE）是位于视网膜感光器细胞和和脉络膜之间的一层单层细胞。本文介绍了RPE细胞的分离、培养和内、外路两种不同的手术方法。从术后活体和组织学检查表明，视网膜下腔是一免疫赦免区域。通过对首次异体移植培养的胎儿RPE细胞病例的临床随访显示，所移植的RPE细胞在黄斑区均能存活，并且具有注视功能。术后囊样黄斑水肿是最主要的并发症，是宿主免疫排斥反应的结果。因此预防和处理移植物的免疫排斥，是手术成功的关键。
Retinal pigment epithelium (RPE) is a monolayer of cells located between retinal photoreceptor cells and the choroid. This article describes the RPE cell isolation, culture and internal and external ways of two different surgical methods. Post-operative biopsies and histological examination revealed that the subretinal space is an immunopapillary area. The clinical follow-up of fetal RPE cells cultured for the first time in allograft showed that the transplanted RPE cells could survive in the macula and have fixation function. Postoperative cystoid macular edema is the most important complication and is the result of host immune rejection. Therefore, prevention and treatment of graft rejection is the key to successful operation.