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实验采用结扎 Wistar 大鼠胆总管制成阻塞性黄疸的动物模型,设三个实验组:胆总管结扎组、手术对照组和正常对照组。三周后采血剖杀,做肝脏、脾脏、肠系膜淋巴结内脏器官的细菌培养,同时取盲肠做盲肠内容物细菌计数。肝脏、脾脏、肠系膜淋巴结细菌培养阳性者称细菌移位。结果显示:胆总管结扎组细菌移位明显增高,而对照组则较低;同时,胆总管结扎组盲肠内细菌计数明显高于对照组。根据上述结果,对阻塞性黄疸时败血症的发生原因进行了探讨。
Experimental animal model of obstructive jaundice was made by ligating the common bile duct of Wistar rats. Three experimental groups were established: common bile duct ligation group, operation control group and normal control group. Blood was sacrificed three weeks later, and bacterial culture of liver, spleen and mesenteric lymph nodes were performed. The caecal contents of the cecum were counted for bacterial counts. Liver, spleen, mesenteric lymph node bacterial culture positive said bacterial translocation. The results showed that the bacterial translocation in the common bile duct ligation group was significantly higher than that in the control group, while the bacterial count in the cecum of the common bile duct ligation group was significantly higher than that in the control group. According to the above results, the cause of sepsis in obstructive jaundice was discussed.