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目的探讨重度吸烟与脑梗死及血清IL-6水平的关系。方法将474例急性脑梗死的住院患者分为重度吸烟和非重度吸烟组,对两组患者在脑梗死的预后、发病年龄、梗死体积、痴呆、出血性梗死及血清IL-6水平等方面进行比较。结果重度吸烟组较非重度吸烟组发病年龄提前(P<0.05),梗死体积大(P<0.05),发生痴呆及出血性梗死者多(P<0.05),血清IL-6水平亦高(P<0.05)。结论本研究为吸烟损害脑血管提供了重要的临床神经生化方面的依据,从而对吸烟有害人体健康这一传统观念有更深刻的理解。
Objective To explore the relationship between severe smoking and cerebral infarction and serum IL-6 levels. Methods A total of 474 hospitalized patients with acute cerebral infarction were divided into two groups: severe smoking and non-severe smoking. The prognosis, the age of onset of infarction, infarct volume, dementia, hemorrhagic infarction and serum IL-6 levels were compared between the two groups Compare Results Compared with non-severe smoking group, the onset age of severe smoking group was higher (P <0.05), infarct volume was larger (P <0.05), dementia and hemorrhagic infarction were more (P <0.05), serum IL- <0.05). Conclusion This study provides an important clinical neurobiochemical basis for smoking to damage cerebrovascular and therefore has a deeper understanding of the traditional concept of smoking harmful to human health.