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报道丁公藤注射液在家兔体内的药代动力学过程，采用荧光检测的反相高效液相色谱法测定丁公藤注射液有效成分东莨菪内酯在血中的浓度。东莨菪内酯在家兔体内呈现双峰现象，吸收较快，个体差异大，平均第一峰达峰时间：Ｔｍａｘ１＝（８．０８±３．８８）ｍｉｎ，第一峰浓度ＬＣｍａｘ１＝（１４５．４５±４７．６５）ｎｇ／ｍｌ。第二峰达峰时间：（２．４５±１．７９）ｈ，第二峰浓度为（４８．６６±４１．６６）ｎｇ／ｍｌ。其它的药代动力学参数为：Ｋｅ＝（０．５６±０．３７）ｈ－１，Ｔ１／２＝（１．８１±１．１４）ｈ，ＭＲＴ＝１５６．６１±９８．４１，ＣＬ／Ｆ＝（２２０．５４±１０９．３５）ｍｌ／ｍｉｎ，Ｖｄ／Ｆ＝（３０．４９±１９．３４）Ｌ，ＡＵＣ＝（８．５２±５．１５）μｇ．ｍｉｎ／ｍｌ。对于产生双峰现象的原因进行了讨论。
The pharmacokinetics of Ding Gong Teng injection in rabbits was reported. The concentration of scopoletin in the blood of Ding Gong Teng Injection was determined by reversed-phase high-performance liquid chromatography with fluorescence detection. Scopolactone showed bimodal phenomenon in rabbits with fast absorption and large individual difference. The average peak time of the first peak was: Tmax1 = (8.08 ± 3.88) min, the first peak concentration LCmax1 = (145 .45 ± 47.65) ng / ml. Peak time of the second peak: (2.45 ± 1.79) h, the second peak concentration (48.66 ± 41.66) ng / ml. Other pharmacokinetic parameters were Ke = (0.56 ± 0.37) h-1, T1 / 2 = (1.81 ± 1.14) h, MRT = 156.61 ± 98.41, CL /F=(220.54 ± 109.35) ml / min, Vd / F = (30.49 ± 19.34) L, AUC = (8.52 ± 5.15) μg. min / ml. The reason for the bimodal phenomenon is discussed.