磺脲类药物作为口服降糖药家族中最早成员之 一,经历了半个多世纪考验,现仍然是临床上重要的口 服降糖药。第一代磺脲类药物由于其单位剂量大,与 磺脲类受体亲和力低、脂溶性差、对细胞穿透性差等原 因,现临床上使用已越来越少。目前应用于临床的多 为第二代、第三代磺脲类药物 Sulfonylureas, one of the earliest members of oral hypoglycemic agents, have undergone more than half a century of tests and are still clinically important oral hypoglycemic agents. The first generation of sulfonylureas because of its unit dose, low affinity with sulfonylurea receptors, poor lipid solubility, poor cell penetration and other reasons, are now less and less clinical use. Currently used in clinical mostly for the second generation, the third generation of sulfonylurea drugs