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目的：探讨EB病毒早期抗原（EA）IgG抗体测定在鼻咽癌筛查中的价值。材料和方法：依序列测定方法，用免疫酶染色法对从6257份血清筛查后获得的，IgA／VCA滴度≥1：80的158例血清再进行EBVIgG／EA酶联免疫吸附法（ELISA）测定和IgA／EA抗体免疫酶染色法测定。同时对上述158例血清阳性者进行鼻咽光纤镜和病理检查。根据检查结果比较单项阳性与双项检查阳性血清间鼻咽癌的检出率（阳性预示值）。结果：在这158例阳性血清者中检出鼻咽癌12例。三组阳性血清诊断鼻咽癌的预示值分别是，第一组（IgA／VCA≥1：80）为7．6％（12／158），第2组（IgA／VCZ≥1：80＋IgA／EA≥1：5）为18．2％（8／44），第3组（lgA／VCA≥1：8和lgG／EAOD值≥0．18）为15．9％（11／69）。第一组的阳性预示值最低（P＜0．05），其余两组间无差异P＞005）。第3组检出的11例鼻咽癌包括了第2组中所有的8例鼻咽癌和另外3例IgA／EA阴性鼻咽癌。结论：从序列测定获得的双项阳性血清中筛查到的鼻咽癌比率高于单项lgA／VCA阳性血清。用IgG／EA与IgA／VCA组合测定的双项阳性血清比用IgA／EA与IgA／VCA组合测定的双项阳性血清能查出更多的鼻咽癌，因此该组合更适合于鼻咽癌筛查。
Objective: To investigate the value of Epstein-Barr virus early antigen (EA) IgG antibody in nasopharyngeal carcinoma screening. MATERIALS AND METHODS: 158 serum samples with IgA / VCA titer≥1: 80 obtained from 6257 serum samples were further subjected to EBVIgG / EA enzyme-linked immunosorbent assay (ELISA) ) Assay and IgA / EA antibody immunoenzyme staining. At the same time 158 cases of seropositive were nasopharyngeal fibroscopy and pathological examination. According to the test results, the positive rate of nasopharyngeal carcinoma between single positive and double check positive serum was compared (positive predictive value). Results: Nasopharyngeal carcinoma was detected in 12 out of 158 positive sera. The predictive value of three groups of positive serum for the diagnosis of nasopharyngeal carcinoma were 7.6% (12/158) in the first group (IgA / VCA≥1: 80), the second group (IgA / VCZ≥1: 80 + IgA / EA ≥1: 5) was 18.2% (8/44), and 15.9% (11/69) in group 3 (lgA / VCA≥1: 8 and lgG / EAOD≥0.18). The positive predictive value of the first group was the lowest (P <0.05), the other two groups no difference P> 005). The 11 NPCs detected in group 3 included all 8 NPCs in group 2 and another 3 NPCs negative for IgA / EA. CONCLUSIONS: Nasopharyngeal carcinoma was screened out of bi-positive sera obtained by sequence analysis higher than single lgA / VCA positive sera. Binary positive sera measured with a combination of IgG / EA and IgA / VCA detected more nasopharyngeal carcinoma than the bi-positive sera measured with a combination of IgA / EA and IgA / VCA and therefore the combination is more suitable for nasopharyngeal carcinoma Screening.