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为探讨肝炎病毒（ＨＶ）与ＥＢ病毒（ＥＢＶ）重叠感染的状况和后果，我们用免疫酶法对１５４例各型病毒性肝炎患者作了ＥＢＶＩｇＡ抗体检测。结果发现，急性肝炎、慢性轻度肝炎、慢性中度肝炎、肝炎肝硬化、慢性重型肝炎和原发性肝癌ＶＧＡ－ＩｇＡ抗体的阳性率分别为２４．０％、３０．０％、５３．３％、６３．３％、４０．０％和７２．７％，与健康人（５．３％）比较，有非常显著升高（Ｐ＜０．０１）；原发性肝癌又较急性肝炎和慢性轻度肝炎高，并有非常显著意义差异（Ｐ＜０．０１）。ＨＢＶ和ＨＡＶ＋ＨＢＶ感染者比较，前者又较后者低（Ｐ＜０．０１）。重叠感染者的临床表现均为“肝炎型”，未见咽炎、腺热、胃肠、肺炎、肾炎、神经等类型。重叠感染者的ＣＤ＋３及ＣＤ＋４Ｔ细胞下降，ＣＤ＋８Ｔ细胞及ＩｇＧ，ＩｇＭ升高，与健康人比较差异非常显著意义（Ｐ＜０．０１）。结果提示：ＨＶ感染，不仅因免疫失调易感ＥＢＶ，又可因重叠感染而进一步使免疫功能失调；对病毒性肝炎的处理应强调免疫调节治疗。
To investigate the status and consequences of over-infection of hepatitis virus (HV) and Epstein-Barr virus (EBV), we detected EBV IgA antibodies against 154 viral hepatitis patients by immunoenzymatic assay. The results showed that the positive rates of VGA-IgA antibody in acute hepatitis, chronic mild hepatitis, chronic moderate hepatitis, cirrhosis, chronic severe hepatitis and primary liver cancer were 24.0%, 30.0%, 53.3 %, 63.3%, 40.0% and 72.7%, respectively, compared with those in healthy subjects (5.3%) (P <0.01) Chronic mild hepatitis is high and has very significant difference (P <0.01). HBV and HAV + HBV infection, the former is lower than the latter (P <0.01). The clinical manifestations of overlapping infections are “hepatitis type”, no pharyngitis, glandular heat, gastrointestinal, pneumonia, nephritis, nerves and other types. The CD + 3 and CD + 4T cells of CD + 8 T cells and IgG and IgM of CD + 8 T cells were significantly increased in over-infected patients (P <0.01). The results suggest that: HV infection, not only because of immune disorders susceptible to EBV, but also due to overlapping infections and further to make immune dysfunction; treatment of viral hepatitis should emphasize immunomodulatory treatment.