论文部分内容阅读
在系统性红斑狼疮脏器病变最具代表性的狼疮性肾炎当中,显示为弥慢性增殖性肾炎者,多半呈现肾病综合征。临床上需要长期应用大剂量类固醇激素治疗。但是不少病例耐受治疗而出现进行性肾功能低下。且经过一个较长的疗程后多伴有明显的副作用。消化性溃疡、糖尿病、严重感染、非血管性骨坏死、骨质疏松症等已成为一临床问题。类周醇激素冲击疗法与原来所应用的大剂量类固醇激素疗法(相当于强地松龙50～60mg/日)比较,是短期内静脉点滴超大剂量类固醇激素的治疗方法。冲击疗法就是在短时间内静脉点滴甲基强地松龙1000mg,连用3天。为了取得更理想的疗效,在冲击
In systemic lupus erythematosus organ lesions among the most representative of lupus nephritis, showed diffuse chronic proliferative glomerulonephritis, mostly nephrotic syndrome. Long-term clinical need for high-dose steroid treatment. However, many cases of resistance to treatment and progressive renal dysfunction. And after a longer course of treatment with more obvious side effects. Peptic ulcer, diabetes, severe infection, non-vascular osteonecrosis, osteoporosis, etc. have become a clinical problem. Weekly alcohol hormone shock therapy and the original application of high-dose steroid hormone therapy (equivalent to prednisolone 50 ~ 60mg / day) is short-term intravenous ultra-high-dose steroid treatment. Impact therapy is in a short time intravenous methylprednisolone 1000mg, once every 3 days. In order to achieve a more ideal effect, the impact