抗生素2488是由放线菌SIA-2488产生的一组碱性十六员环大环内酯类物质。它们抗革蓝氏阳性细菌,特别对红霉素耐药菌和青霉素耐药菌有效。经化学鉴别本组抗生素属于柱晶白霉素(Leucomycin)——麦迪霉素(Midecamycin)族,其主要组分SA_1、SA_2、SB_1、SB_2分别与柱晶白霉素A_3、A_4、A_1、A_5相同(图1)。本文报道抗生素2488的分离纯化及四个组分的理化性质和结构鉴别。 Antibiotic 2488 is a group of basic sixteen-membered macrolide species produced by actinomycete SIA-2488. They are resistant to Gram-positive bacteria, especially erythromycin-resistant and penicillin-resistant bacteria. The chemical identification of this group of antibiotics belongs to Leucomycin - Midecamycin family, the main components of SA_1, SA_2, SB_1, SB_2, respectively, and leucomycin A_3, A_4, A_1, A_5 The same (Figure 1). This article reports the isolation and purification of antibiotic 2488 and the physical and chemical properties and structural identification of the four components.