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目的:研究三七提取液对阿尔茨海默病模型小鼠的保护作用。方法:以葡萄糖酸铝ig小鼠以复制阿尔茨海默病模型。实验分为5组,即正常、模型、石杉碱甲和三七总皂苷(PNS)高、低剂量组,ig给药,每天1次,每周5d,连续3月。复制模型同时ig给药。通过跳台法观察小鼠的被动回避性学习能力,测定丙二醛(MDA)含量、超氧化物歧化酶(SOD)和乙酰胆碱转移酶(ChAT)活性。结果:与模型组比较,PNS高、低剂量组训练次数显著减少(P<0.01或P<0.05),潜伏期显著缩短(P<0.01);PNS高、低剂量组MDA含量显著减少,SOD和ChAT活性显著增强(P<0.01)。结论:PNS可通过降低MDA含量,增强SOD和ChAT活性的途径减缓老年痴呆病变状态。
Objective: To study the protective effect of Panax notoginseng extract on Alzheimer’s disease model mice. Methods: Aluminum gluconate ig mice were used to replicate the Alzheimer’s disease model. The experiment was divided into five groups, normal, model, huperzine A and Panax notoginseng saponins (PNS) high and low dose group, ig administration, once a day, 5days a week for three consecutive months. Copy the model while ig administration. The passive avoidance learning ability of mice was observed by jumping platform method. The content of malondialdehyde (MDA), the activity of superoxide dismutase (SOD) and the activity of acetylcholinesterase (ChAT) were measured. Results: Compared with the model group, the numbers of training in PNS high and low dose groups were significantly decreased (P <0.01 or P <0.05), the incubation period was significantly shortened (P <0.01); MDA content in PNS high and low dose groups was significantly decreased, while SOD and ChAT Activity was significantly enhanced (P <0.01). Conclusion: PNS can slow down the pathological changes of Alzheimer’s disease by decreasing the content of MDA and enhancing the activity of SOD and ChAT.