趋化因子受体属于G蛋白偶联受体超家族,是含7个穿膜区段的单链受体,胞内区与G蛋白偶联,可产生信号转导。其在多种肿瘤细胞和肿瘤间质细胞膜上有功能性表达,趋化因子受体与肿瘤多种生物学行为密切相关。在肿瘤血管生成中,不同的趋化因子产生不同的生物学效应,提示可能存在不同的作用机制,成为新的抗癌策略靶点。 Chemokine receptors belong to the superfamily of G protein-coupled receptors, which are single-stranded receptors containing seven transmembrane segments that are coupled to G proteins to produce signal transduction. It is expressed in a variety of tumor cells and tumor stromal cell membranes, chemokine receptors and tumor biological behavior is closely related. In tumor angiogenesis, different chemokines produce different biological effects, suggesting that there may be different mechanisms of action, a new anticancer strategy target.