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应用体外淋转分析法,以PHA诱发淋巴细胞增殖强度为指标,对52例慢阻肺患者的细胞免疫功能作了观察,并与71例正常人作对照,再从血浆、单核细胞和淋巴细胞三方面分析造成低反应的主要因素。结果发现慢阻肺患者体外淋转反应比正常老人明显降低(P<0.01),当以等量正常人混合血清取代患者血浆后,可便淋转反应值增高但仍未能达到健康老人水平(P<0.01),提示除了存在血浆抑制因子外,体外淋转低反应还另有原因。当去除粘附细胞(Ac)以后,其淋转值更低,回加Ac后,淋转值有较大幅度的回升(1.35倍),但仍低于正常老人(P<0.05),提示慢阻肺患者单核细胞(Mc)协助功能不良,而且其淋巴细胞(LC)功能也有改变。这样,慢阻肺患者细胞免疫功能减退的原因,就同时包括淋巴细胞、单核细胞和血浆因子三个方面。
In vitro lymphatic analysis was used to measure the cellular immune function of 52 COPD patients, and the results were compared with that of 71 normal controls. The plasma, monocytes and lymph Cell analysis of the three major factors that cause low response. The results showed that patients with chronic obstructive pulmonary disease had significantly lower lymph node reaction than normal controls (P <0.01). When the patient’s plasma was replaced by an equal amount of normal human serum, the lymph node reaction value increased but failed to reach the healthy level P <0.01), suggesting that in addition to the presence of plasma inhibitors, in vitro lymphatic metastasis low reaction is another reason. When Ac (Ac) was removed, its leaching value was lower. After adding Ac, the leaching value increased a little (1.35 times), but still lower than that of normal (P <0.05) Monocytes in patients with lung disease (Mc) assist dysfunction, and its lymphocyte (LC) function also changed. In this way, COPD patients with cellular immune function decline, including both lymphocytes, monocytes and plasma factors in three areas.