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探讨失血性休克再灌注复苏后血浆中降钙素基因相关肽（ＣＧＲＰ）改变的意义，早期使用磷脂酶Ａ２（ＰＬＡ２）阻断剂、抗氧化剂对ＣＧＲＰ的影响及其与ＰＬＡ２激活、氧自由基产生的关系。家兔失血性休克维持６０分钟后回输自体血液及平衡盐液，血浆中ＣＧＲＰ逐渐升高，复苏后６小时达顶点，同出血前比较有显著性差异（Ｐ＜０．０５）；ＰＬＡ２阻断剂氯喹及ＭＥ８１０１、抗氧化剂黄芪酮于失血后复苏前使用可明显抑制复苏后血浆中ＣＧＲＰ的增高；同时，复苏后家兔平均动脉压（ＭＡＰ）和血ｐＨ值逐渐下降，与ＣＧＲＰ变化没有明显相关（ｒ＝０．００４０和ｒ＝０．０４３５）；假手术造成血浆ＣＧＲＰ水平复苏后逐渐上升，同术前比较差异同样显著（Ｐ＜０．０５），但并不伴随ＭＡＰ和ｐＨ值的下降，氯喹、ＭＥ８１０１及黄芪酮纠正酸中毒、维持血压稳定的作用与抑制ＣＧＲＰ并无明显相关。结果提示：家兔失血性休克后再灌注复苏过程中血浆ＣＧＲＰ水平的上升可能不是ｐＨ值和ＭＡＰ下降的重要因素；ＰＬＡ２阻断剂和抗氧化剂并非通过抑制ＣＧＲＰ上升而产生抗酸中毒及稳定循环血压的作用
To investigate the significance of the changes of plasma calcitonin gene-related peptide (CGRP) after hemorrhagic shock-reperfusion resuscitation. The effects of early use of phospholipase A2 (PLA2) blockers and antioxidants on CGRP and its interaction with PLA2 activation, oxygen free radicals Generated by the relationship. After 60-minute hemorrhagic shock, rabbits were transfused with autologous blood and balanced salt solution. The level of plasma CGRP increased gradually, reached the peak at 6 hours after resuscitation, which was significantly different from that before hemorrhage (P <0.05). PLA2 Clearing agents chloroquine and ME8101 and anti-oxidant astragalus could significantly inhibit the increase of plasma CGRP after resuscitation, meanwhile, the mean arterial pressure (MAP) and blood pH of rabbits decreased gradually after resuscitation, but not with the change of CGRP (R = 0.0040 and r = 0.0435). The levels of plasma CGRP in sham operation increased gradually after resuscitation, which were also significantly different from those before operation (P <0.05), but not associated with MAP and pH Of the decline, chloroquine, ME8101 and astragalus correct acidosis, to maintain the role of blood pressure stability and inhibition of CGRP no significant correlation. The results suggest that the rise of plasma CGRP during resuscitation after hemorrhagic shock in rabbits may not be an important factor in the decrease of pH and MAP; PLA2 blockers and antioxidants do not produce antacidosis and stable circulation by inhibiting the increase of CGRP The role of blood pressure