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本文研究血管紧张素Ⅰ转化酶(ACE)抑制剂巯甲丙脯酸对大鼠缺氧性肺动脉高压的作用。实验结果表明,该制剂长期口服能部分地减轻由慢性缺氧所引起的肺动脉高压和右心室肥大。慢性缺氧还可使肺循环中ACE活性降低和肺血管对血管紧张素Ⅱ及急性缺氧的收缩反应减弱。从而提示在慢性缺氧过程中,肺循环中血管紧张素Ⅱ生成减少,对缺氧性肺动脉高压的发生、发展起调节作用。
This article studies the effect of angiotensin I converting enzyme (ACE) inhibitor captopril on hypoxic pulmonary hypertension in rats. The experimental results show that the long-term oral administration of the preparation can partially relieve pulmonary hypertension and right ventricular hypertrophy caused by chronic hypoxia. Chronic hypoxia may also reduce ACE activity in the pulmonary circulation and pulmonary vascular contractile response to angiotensin II and acute hypoxia. This suggests that during the process of chronic hypoxia, the production of angiotensin Ⅱ in the pulmonary circulation is reduced, which plays a regulatory role in the occurrence and development of hypoxic pulmonary hypertension.