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西米替丁为组胺（H2）受体拮抗剂，自1977年以来广泛用于消化性溃疡的治疗。许多研究证实，西米香丁具有免疫增强作用和抗肿瘤作用。有关西米替丁对胃癌的治疗作用和是否诱发胃癌的问题逐渐被认识。一、西米替了的作用机理1987年Avella首先提出西米替了可增强机体的免疫功能。?
Cimitidine is a histamine (H2) receptor antagonist and has been widely used for the treatment of peptic ulcer since 1977. Many studies have confirmed that samidine has an immunopotentiating and antitumor effect. The question of the therapeutic effect of cimetidine on gastric cancer and whether it induces gastric cancer has been gradually recognized. First, the mechanism of action of cimitidine In 1987, Avella first proposed that sirometrian can enhance the body’s immune function. ?