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目的了解云南省德宏州傣、景颇、德昂、阿昌族0-7岁G6PD缺乏症的流行病学现状。方法对云南省德宏州傣、景颇、德昂、阿昌族7岁以下儿童共2192人,进行了血液分析、Hb电泳、G6PD/6PGD定量比值法检测,并进行统计学分析。结果所调查的地区G6PD缺乏症发生率6.6%,不同年龄G6PD缺乏率各年龄组无明显差异,不同年龄G6PD缺乏率男女童有明显差异,男童明显高于女童;G6PD缺乏率以德昂族8.4%居首,各民族之间差异无显著意义;G6PD缺乏率以盈江县7.9%居高,各地区之间差异无统计学意义。结论 G6PD缺乏率无论单因素分析,还是多因素分析男童高于女童,符合X伴性遗传方式;G6PD缺乏率虽然与民族有关,更重要的与地域有关,该调查为云南省德宏州少数民族进行遗传咨询及进行G6PD缺乏症的预防提供了有价值的基础资料。
Objective To understand the epidemiological status of G6PD deficiency in 0-7 years old in Dai, Jingpo, Deang and Achang of Dehong prefecture in Yunnan province. Methods A total of 2192 children under 7 years old from Dai, Jingpo, Deang and Achang of Dehong prefecture in Yunnan province were tested by hematology analysis, Hb electrophoresis and quantitative method of G6PD / 6PGD, and statistical analysis was made. Results The prevalence of G6PD deficiency in the surveyed areas was 6.6%. There was no significant difference in the incidence of G6PD deficiency among different age groups. There was a significant difference between boys and girls in G6PD deficiency rate at different ages. The G6PD deficiency rate was significantly lower in De’an 8.4 % Top, no significant difference between the various ethnic groups; G6PD deficiency rate of 7.9% in Yingjiang County, no significant difference between regions. Conclusions G6PD deficiency rate is higher than that of girls in boys regardless of univariate analysis or multivariate analysis, which is consistent with X-linked sex. G6PD deficiency rate is related to ethnic groups and more importantly, Ethnic genetic counseling and prevention of G6PD deficiency provide valuable basic information.