生殖是一个复杂的生理过程,生殖细胞的生长、发育、成熟、受精以及胚胎着床、发育等受多种细胞因子的调控。卵巢内微环境中调节卵泡发育的细胞因子日益受到重视,白细胞介素(IL)是一类具有广泛生物学活性的激素样多肽,作为免疫细胞之间进行信息传递的信号,主要以局部的自分泌和旁分泌方式发挥生物效应,通过与免疫细胞表面的受体结合,使免疫细胞活化、增生、分化,直接或间接调节生殖过程的各个环节。就IL-15,IL-18及IL-12/IL-23亚基p40近几年在生殖领域的研究做一综述。 Reproduction is a complex physiological process. The growth, development, maturation, fertilization, embryo implantation and development of germ cells are regulated by many cytokines. Increasing attention has been paid to the cytokines that regulate follicular development in the ovarian microenvironment. Interleukins (ILs) are a class of hormone-like polypeptides with a wide range of biological activities that serve as signals for the transmission of information between immune cells, Secretion and paracrine way to play a biological effect, through the immune cell surface receptors, so immune cell activation, proliferation, differentiation, direct or indirect regulation of all aspects of the reproductive process. This review summarizes the recent studies on the reproductive field of IL-15, IL-18 and IL-12 / IL-23 subunit p40.