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目的:定量分析CerbB-2和CD34在浸润性导管癌中的表达特点,并探讨其相互关系。方法:应用免疫组化检测102例浸润性导管癌原发灶组织中CerbB-2和CD34蛋白的表达,用图像分析软件对CerbB-2阳性单位(PU)进行定量测试,计数200倍镜下CD34标记阳性的微脉管数即MVD。结果:CerbB-2蛋白定量表达和MVD均与浸润性乳腺癌肿瘤的直径、淋巴结转移、组织的分级和TNM分期有关(P<0.05),二者之间呈正相关(r=0.546,P=0.000)。结论:CerbB-2和CD34二者可能相互作用对浸润性导管癌的发展起到一定的作用。
Objective: To quantitatively analyze the expression of CerbB-2 and CD34 in invasive ductal carcinoma and to explore the relationship between them. Methods: The expression of CerbB-2 and CD34 protein in 102 cases of primary invasive ductal carcinomas was detected by immunohistochemistry. CerbB-2 positive units (PU) were quantitatively analyzed by image analysis software. The number of CD34 Marked positive microvascular number that MVD. Results: The quantitative expression of CerbB-2 protein and MVD were correlated with the diameter, lymph node metastasis, histological grade and TNM stage of invasive breast cancer (P <0.05), and there was a positive correlation between CerbB-2 protein and MVD (r = 0.546, ). Conclusion: The possible interaction between CerbB-2 and CD34 play a role in the development of invasive ductal carcinoma.