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目的分析2011年泉州市疑似预防接种异常反应(AEFI)的发生特征,评价AEFI监测系统运转情况。方法通过收集国家AEFI监测系统报告的泉州市2011年AEFI个案数据,采用描述性分析方法对监测资料进行分析。结果 2011年泉州市AEFI监测系统接到报告226例病例,县覆盖率100%,48h及时报告率为91.15%,48h内调查率95.65%,个案调查表调查后3d内报告率为73.91%。报告发生年龄67.70%≤1岁,61.50%发生在第1剂次,89.82%发生在接种后≤1d,报告高峰在6-9月,百白破疫苗占56.19%。一般反应占80.09%(181/226),异常反应占16.81%(38/226),异常反应以过敏性反应为主,过敏性反应中以过敏性皮疹为多。报告发生率为6.69/10万剂次,国家免疫规划疫苗报告发生率前三位为无细胞白百破疫苗、麻风疫苗、白破疫苗。结论 2011年泉州市预防接种异常反应监测系统运行在敏感性和及时性较往年有明显提高,报告成常规化、系统化态势,但尚需进一步完善和规范。
Objective To analyze the occurrence of suspected AEFI in Quanzhou in 2011 and evaluate the operation of AEFI monitoring system. Methods The AEFI data collected in 2011 by the national AEFI monitoring system were collected and the descriptive analysis method was used to analyze the monitoring data. Results A total of 226 cases were reported in Quanzhou AEFI monitoring system in 2011. The coverage rate of county was 100%. The timely reporting rate was 91.15% within 48 hours and 95.65% within 48 hours. The reported rate of 73.91% within three days after investigation. Reported the age of 67.70% ≤ 1 years old, 61.50% occurred in the first dose, 89.82% occurred after inoculation ≤ 1d, the report peak in the 6-9 months, diphtheria vaccine accounted for 56.19%. The common reactions accounted for 80.09% (181/226), abnormal reactions accounted for 16.81% (38/226), anaphylaxis with anaphylactic reactions, allergic reactions with allergic rashes. The report rate was 6.69 / 100 000 doses. The first three cases of the national immunization program vaccine report were acellular leucomycin vaccine, leprosy vaccine and white broken vaccine. Conclusion The monitoring system of immunization in Quanzhou in 2011 has been significantly improved in sensitivity and timeliness as compared with previous years. The report has become normalized and systematized but needs further improvement and standardization.