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目的:采用一测多评技术建立UPLC快速测定淫羊藿总黄酮胶囊中7种成分(朝藿定A1,朝霍定A,朝霍定B,朝霍定C,淫羊藿苷,鼠李糖基淫羊藿次苷Ⅱ以及宝霍苷I)的方法,并验证此方法在淫羊藿总黄酮胶囊中应用的可行性和方法适用性。方法:以淫羊藿总黄酮胶囊中7个具异戊烯基取代的黄酮类成分为指标成分,在一定的线性范围内,建立淫羊藿苷与其他6个成分的相对校正因子,计算朝藿定A1,朝霍定A,朝霍定B,朝霍定C,鼠李糖基淫羊藿次苷Ⅱ以及宝霍苷I的含量,实现一测多评。结果:各成分相对淫羊藿苷的校正因子分别为f_(淫羊藿苷)/f_(朝藿定A)1=1.413,f_(淫羊藿苷)/f_(朝藿定A)=1.231,f_(淫羊藿苷)/f_(朝藿定B)=1.375,f_(淫羊藿苷)/f_(朝藿定C)=1.166,f_(淫羊藿苷)/f鼠李糖基淫羊藿次苷Ⅱ=0.962,f_(淫羊藿苷)/f宝藿苷Ⅰ=0.689,且重复性良好,10批淫羊藿总黄酮胶囊中7个成分的计算值与外标法实测值无明显差异。结论:一测多评法可用于淫羊藿总黄酮胶囊中多成分的质量评价,结果稳定可靠。
OBJECTIVE: To establish a rapid and sensitive method for the determination of seven components in Epimedium Flavonoids Capsules (Epimedin A1, Asahidin A, Asahidin B, Asarum C, Icariin, Glycyrrhizin glycosides Ⅱ and boswellin I) method, and to verify the feasibility of this method in the application of total flavonoids Epimedium and the applicability of the method. Methods: Seven isopentenyl-substituted flavonoids in Epimedium Flavum Capsules were used as the index components to establish the relative correction factors of icariin and other six components in a certain linear range. Toasto A1, towards Huo Ding A, toward Huo Ding B, toward Huo Ding C, rhamnosyl Icariin and asparagine I content, to achieve a test of multiple comments. Results: The calibration factors of each component relative to icariin were f_ (icariin) / f_ (epimedin A) 1 = 1.413, f_ (icariin) / f_ (epimedin A) = 1.231 , f_ (icariin) / f_ (epimedin B) = 1.375, f_ (icariin) / f_ (epimedin C) = 1.166, f_ (icariin) / f rhamnosyl Epimedium Ⅱ = 0.962, f_ (icariin) / f icoperitone Ⅰ = 0.689, and good reproducibility, 10 batches of Epimedium total flavonoids in seven components of the calculated value and the external standard measured No significant difference in value. Conclusion: The first test multiple evaluation method can be used for the quality evaluation of Epimedium Flavum Capsules multi-component, the results are stable and reliable.