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目的:研究不同厂家和不同批次黄连上清片指纹图谱及色谱峰面积的差异。方法:采用高效液相色谱法,比较不同厂家和同一厂家不同批次黄连上清片特征指纹图谱的差异,并通过相似度软件分析其相似性。结果:不同厂家生产的黄连上清片在所含色谱峰的数目和峰面积上存在很大差异;同一厂家不同批号黄连上清片所含色谱峰的数目基本相同,含量虽然存在一定的差异,但相对不同厂家的差异较小。结论:不同厂家的黄连上清片指纹图谱变异范围差异较明显,同一厂家的产品质量基本稳定在一定水平内。
OBJECTIVE: To study the differences of fingerprints and chromatographic peak areas of Coptis chinensis supernatants from different manufacturers and batches. Methods: The HPLC fingerprint was used to compare the fingerprints of different batches of Coptis chinensis from different manufacturers and same manufacturers. The similarities were analyzed by similarity software. Results: Coptis clear tablets produced by different manufacturers contained a great difference in the number and peak area of the chromatographic peaks contained; although the number of chromatographic peaks contained in the same batch of different batch Coptis of the same manufacturer was basically the same, although there were some differences in the content, However, the difference is relatively small different manufacturers. Conclusion: There are obvious differences in the fingerprints of Coptis chinensis supernatants from different manufacturers. The product quality of the same manufacturer is basically stable within a certain level.