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Early diagnosis and prompt treatment aremandatory to prevent colorectal cancer. Detection offree circulating tumor DNA in the serum of the cancer patients provides new possibilities for cancer diagnosis. Several circulating colorectal cancer DNAs have beenidentified by PCR detection such as the activated K-ras oncogene, inactivated APC, p53 genes, andmicrosatellite instability (MSI). Circulating tumor DNA was predominantly found in patients with advanceddisease and poor prognosis. It was suggested thatanalysis for circulating tumor DNA might be useful in early diagnosis.
Detection of free circulating tumor DNA in the serum of the cancer patients provides new possibilities for cancer diagnosis. Several circulating colorectal cancer DNA DNA have been identified by PCR detection such as the activated K-ras oncogene, inactivated APC, p53 genes, and microsatellite instability (MSI). Circulating tumor DNA was predominantly found in patients with advanced disease and poor prognosis. It was suggested that analysis for circulating tumor DNA might be useful in early diagnosis.