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目的:探讨非多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者发生卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)的高危因素。方法 :回顾性分析80例非PCOS行体外受精(in vitro fertilization,IVF)周期者,分为发生OHSS及未发生OHSS组,比较2组患者的基础指标及IVF周期相关指标的差异情况。结果:相较于未发生OHSS者,发生OHSS的患者年龄轻、体质量指数(body mass index,BMI)低、血清抗苗勒管激素(anti-Müllerian hormone,AMH)水平高、睾酮水平高、窦卵泡数目多,注射人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)日直径≥14 mm卵泡数目多、注射HCG日血清雌二醇(estradiol,E2)值高、取卵数目、MII期卵母细胞数目均多(P<0.05)。结论:年龄轻、BMI低、AMH水平高、睾酮水平高、窦卵泡数目多、注射HCG日直径≥14 mm卵泡数目多、注射HCG日血清E2值高、取卵数目多、MII期卵母细胞数多的非PCOS患者可能更易发生OHSS。
Objective: To investigate the risk factors of ovarian hyperstimulation syndrome (OHSS) in patients with non-polycystic ovary syndrome (PCOS). Methods: A retrospective analysis of 80 non-PCOS in vitro fertilization (IVF) cycles were divided into OHSS group and non-OHSS group. The difference of basic indexes and IVF cycle-related indexes between two groups were compared. RESULTS: OHSS patients were younger, had lower body mass index (BMI), higher levels of serum anti-Müllerian hormone (AMH), higher levels of testosterone, The number of antral follicles was more than that of human chorionic gonadotropin (HCG). The number of follicles more than 14 mm in diameter on day HCG was higher than that on day HCG The number of blast cells were more (P <0.05). CONCLUSIONS: Young, low BMI, high level of AMH, high level of testosterone, more number of antral follicles, more follicles with a diameter of ≥ 14 mm on day of HCG injection, high value of serum E2 on HCG injection day, number of oocytes retrieved, number of MII oocytes OHSS may be more likely to occur in more non-PCOS patients.