论文部分内容阅读
目的探讨40岁以上女性采用全胚胎玻璃化冻融胚胎移植替代新鲜胚胎移植作为超促排卵体外受精-胚胎移植周期首次移植的可行性。方法回顾性分析中南大学湘雅医院生殖中心2011年4月至2012年2月1863例新鲜胚胎移植周期和1083例玻璃化冻融胚胎移植周期的临床资料,应用多因素Logistic回归方法,分析临床相关因素与临床妊娠率的关系。结果女性年龄超过40岁时,玻璃化冻融胚胎移植的临床妊娠率显著高于新鲜胚胎移植的临床妊娠率(32.56%vs.16.10%,P<0.05);多因素Logistic回归分析显示移植周期类型与临床妊娠密切相关,玻璃化冻融胚胎移植对新鲜胚胎移植的妊娠优势比为2.49(95%CI1.09~5.69,P<0.05)。结论年龄超过40岁女性采用玻璃化冻融胚胎移植可获得比新鲜胚胎移植更好的妊娠结局。
Objective To investigate the feasibility of using full embryo vitrification and thawing embryo transfer instead of fresh embryo transfer as the first transplant of super-ovulation in vitro fertilization-embryo transfer in women over 40 years old. Methods The clinical data of 1863 fresh embryo transfer cycles and 1083 vitrification freeze-thaw embryos transfer cycles from June 2011 to February 2012 in Reproductive Center of Xiangya Hospital of Central South University were retrospectively analyzed. Multivariate Logistic regression was used to analyze the clinical correlation Relationship between factors and clinical pregnancy rate. Results The clinical pregnancy rate of vitrification and embryo transfer was significantly higher than that of fresh embryo transfer (32.56% vs.16.10%, P <0.05) when the female’s age exceeded 40 years old. Multivariate Logistic regression analysis showed that the type of graft cycle Closely related to clinical pregnancy, the odds ratio of pregnancy with fresh embryo transfer was 2.49 (95% CI, 1.09 ~ 5.69, P <0.05). CONCLUSIONS: Women over 40 years of age receive better pregnancy outcomes than fresh embryo transfer using vitrified embryo transfer.