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目的探讨T2DM病程10年以上无微量白蛋白尿患者eGFR下降的危险因素。方法选取T2DM病程10年以上无微量白蛋白尿的患者294例,分为eGFR≥60 ml/(min·1.73 m~2)组及eGFR<60 ml/(min·1.73 m~2)组。Logistic回归分析eGFR下降的危险因素。结果 Logistic回归分析发现,超重、TC升高、冠心病病史、糖尿病家族史是eGFR下降的影响因素。结论 T2DM患者联合检测尿白蛋白/肌酐(UAlb/Cr)及eGFR可全面评估肾功能情况,尤其适用于病程较长的患者。该类患者严格控制体重、TG及动脉粥样硬化等可减少糖尿病慢性肾脏疾病的发病风险。
Objective To investigate the risk factors of eGFR decline in patients with T2DM over 10 years without microalbuminuria. Methods A total of 294 patients with T2DM over 10 years without microalbuminuria were divided into eGFR≥60 ml / (min · 1.73 m ~ 2) group and eGFR <60 ml / (min · 1.73 m ~ 2) group. Logistic regression analysis of eGFR decreased risk factors. Results Logistic regression analysis found that overweight, elevated TC, coronary heart disease and family history of diabetes were the influential factors of eGFR decline. Conclusion The combined detection of urinary albumin / creatinine (UAlb / Cr) and eGFR in patients with T2DM can fully evaluate the renal function, especially in patients with longer duration. Strict control of such patients weight, TG and atherosclerosis can reduce the risk of diabetic chronic kidney disease.