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目的 :探索5 -Fu在青光眼复合式小梁切除术中的合理用药。方法 :随机选择46眼行复合式小梁切除术 ,据年龄、青光眼类型、眼前段结构特点等分成A、B、C3组 ,5 -Fu在3组中使用不同浓度、范围、时间 ,分析比较3组术后前房深度、眼压、滤过泡及术后并发症。结果 :术后第1日 ,A、C组各出现1眼浅前房 ,3组比较前房深度形成无显著差异 (P>0.05)。术后1年随访 ,A组1眼眼压低于6mmHg,而B、C组各有1眼在21mmHg以上。术后眼压以控制在6～21mmHg为手术成功标准 ,A、B、C3组手术成功率分别为93.7 %、93.3 %、93.3 %,3组比较差异无显著性 (P>0.05)。术后3组滤过泡、并发症比较差异均无显著性 (P>0.05)。结论 :5 -Fu使用浓度在25～50mg/ml、时间在2～5分钟是安全、有效的。
Objective: To explore the rational use of 5-Fu in glaucoma trabeculectomy. Methods: A total of 46 eyes underwent trabeculectomy were randomly divided into groups A, B, and C3 according to age, type of glaucoma, structure of the anterior segment of eyes, and 5-Fu in different concentrations, ranges and time in 3 groups Three groups of postoperative anterior chamber depth, intraocular pressure, filtration bleb and postoperative complications. Results: On the first day after operation, one case of shallow anterior chamber appeared in group A and C, and there was no significant difference in depth of anterior chamber in three groups (P> 0.05). One year follow-up showed that IOP in group A was lower than 6mmHg, while that in group B and C was more than 21mmHg. Postoperative IOP was controlled at 6 ~ 21mmHg for successful operation. The successful rates of operation in groups A, B and C3 were 93.7%, 93.3% and 93.3%, respectively. There was no significant difference between the three groups (P> 0.05). There was no significant difference in the complication between the three groups after filtering bleb (P> 0.05). Conclusion: 5-Fu concentration of 25 ~ 50mg / ml, the time in 2 to 5 minutes is safe and effective.