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目的使用人工喷射液滴模拟咳嗽所产生飞沫,研究呼吸道传染病经空气传播的路径,评估室内感染呼吸道传染病的风险建立实地研究方法。方法在洁净度为100级的洁净实验室内以可控方式使用喷嘴喷射含有与人类唾液相似非挥发性的液滴,使用基于光学干涉Mie成像技术的Particle Master IMI系统对液滴的数量及粒径分布进行测量,找到与文献报道的咳嗽所产生颗粒物数量及粒径分布相近数据。结果在选定的喷嘴喷射流量情况下,持续时间为1s喷射过程中,喷嘴出口的液滴数量浓度为4个/mm3,相当于总共喷射出40 500个液滴;喷射液滴粒径的分布特征与从文献数据获得的咳嗽呼出颗粒物的粒径分布曲线非常吻合,其最小平方相关系数(又称决定系数)r2=0.88。结论成功使用具有唾液相似非挥发性组分人工合成物,采用可控方式制造出与咳嗽呼出颗粒物具有类似粒径分布的液滴谱系,为室内呼吸道传染病的飞沫传播路径及其感染风险研究提供了一种实地研究方法。
Objective To use artificial droplet to simulate the droplets produced by cough, to study the route of airborne transmission of respiratory infectious diseases, to evaluate the risk of indoor infectious respiratory diseases and to establish field research methods. Methods In a clean laboratory with a cleanliness level of 100, a droplet containing a nonvolatile droplet similar in size to human saliva was sprayed in a controlled manner using a nozzle in a controlled manner using a Particle Master IMI system based on optical interference Mie imaging to quantify the number of droplet Diameter distribution measurement, find and reported in the literature cough particles generated by the number and size distribution of similar data. Results With a selected nozzle jet flow duration of 1 s, the droplet concentration at the nozzle exit was 4 per mm3, which corresponded to a total of 40 500 droplets ejected; a distribution of jet droplet particle size The characteristics are in good agreement with the particle size distribution curves of cough exhaled particles obtained from the literature data. The least square correlation coefficient (also called the coefficient of determination) r2 = 0.88. Conclusion The successful use of saliva-like non-volatile components of artificial compounds, the use of controlled manner to produce particles with exhaled particles of cough with similar particle size distribution of the droplet line for indoor respiratory infectious droplets pathways and their risk of infection Provides a field research method.