内皮素是一种主要由血管内皮细胞产生的肽类物质,不仅具有强大的血管收缩功能,而且还有一些重要的生理学作用,如组织分化、细胞增殖及激素分泌等。近年来的研究发现内皮素还参与体内多种肿瘤的生长过程,如前列腺癌、宫颈癌、乳腺癌等,其生物学效应的实现可能与促有丝分裂、抑制凋亡、诱导肿瘤生长过程中的血管生成、原癌基因的激活等有关。晚期前列腺癌患者骨转移、成骨作用及疼痛等均与其有关。 Endothelin is a peptide produced mainly by vascular endothelial cells, not only has a strong vasoconstrictive function, but also some important physiological effects, such as tissue differentiation, cell proliferation and hormone secretion. In recent years, the study found that endothelin is also involved in the growth of a variety of tumors in vivo, such as prostate cancer, cervical cancer, breast cancer, the biological effects of its possible mitosis, inhibition of apoptosis, induction of tumor growth during blood vessels Generated, protooncogene activation and so on. Advanced prostate cancer patients with bone metastases, osteogenesis and pain are related to it.