目的观察冠心病并发缺血性脑卒中患者血清同型半胱氨酸(HCY)、血清超敏C反应蛋白(hsCRP)及血脂水平的检测结果,并分析其意义。方法以285例冠心病患者为研究对象,观察组为合并缺血性脑卒中患者112例,对照组为未合并缺血性脑卒中患者173例。检测并对比两组患者的血清HCY、hs-CRP及血脂水平,同时观察不同病情合并缺血性脑卒中患者间的差异。采用SPSS 20.0统计软件进行统计分析,计量资料用均数±标准差(xˉ±s)表示,采用t检验,多组间资料的均数比较采用方差分析(SNK-q法),P<0.05为差异有统计学意义。结果观察组患者血清HCY、hs-CRP、低密度脂蛋白胆固醇(LDL-C)等水平均高于对照组(P<0.05),高密度脂蛋白胆固醇(HDL-C)水平低于对照组(P<0.05)。在HCY、hs-CRP、LDL-C水平上,缺血性脑卒中重度组>中度组>轻度组,差异均有统计学意义(P<0.05);在HDL-C水平上,缺血性脑卒中重度组<中度组<轻度组,差异均有统计学意义(P<0.05)。结论血清HCY、hs-CRP及LDL-C、HDL-C水平与冠心病并发缺血性脑卒中的发生、发展密切相关,通过对冠心病患者这些指标的检测能够为并发缺血性脑卒中发生的预测、病情程度的评估及防治提供参考依据。 Objective To investigate the detection of serum homocysteine ​​(HCY), serum hs-CRP and serum lipids in patients with coronary heart disease and ischemic stroke and to analyze its significance. Methods A total of 285 patients with coronary heart disease were enrolled in this study. The observation group consisted of 112 patients with ischemic stroke and the control group with 173 patients without ischemic stroke. The levels of serum HCY, hs-CRP and serum lipids were detected and compared between two groups. At the same time, the differences between patients with different types of ischemic stroke were observed. Statistical analysis was performed using SPSS 20.0 statistical software. The measurement data were expressed as mean ± standard deviation (x ± s). Student’s t-test was used to compare the mean of data between groups. ANOVA (SNK-q) The difference was statistically significant. Results The serum levels of HCY, hs-CRP and LDL-C in the observation group were significantly higher than those in the control group (P <0.05), and the levels of HDL-C were lower than those in the control group P <0.05). The levels of HCY, hs-CRP and LDL-C in ischemic stroke group were significantly higher than those in moderate group and mild group (P <0.05). At the level of HDL-C, Severe stroke group