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目的:探讨雌激素受体(ER)α基因PvuⅡ多态性与氟暴露地区成人骨组织异常的关系。方法:采用整群抽样方法,在氟病区及对照区选择当地出生或居住5 a以上18~55岁的人群为观察对象;采用PCR-RFLP法分析ERα基因PvuⅡ多态性;采用X线检查两区人群骨组织改变。结果:暴露组和对照组人群骨组织异常率分别为65.34%和40.32%,差异有统计学意义(P<0.05);以pp基因型为参照,暴露组携带Pp/PP人群骨组织异常的危险性增高(PR=1.087,95%CI=1.053~1.437或PR=1.145,95%CI=1.104~1.318)。结论:携带ERαPvuⅡPp/PP基因型可能增加骨组织对氟暴露敏感性。
Objective: To investigate the relationship between the Pvu Ⅱ gene of estrogen receptor (α) gene and the abnormalities of adult bone in exposed areas of fluorosis. Methods: The cluster sampling method was used to select the population of local residents or residents aged 18-55 who were living or living in the endemic fluorosis and control areas. The PCR-RFLP was used to analyze the Pvu Ⅱ polymorphism of ERα gene. Bone tissue changes in two districts. Results: The abnormal rates of bone tissue in exposed group and control group were 65.34% and 40.32%, respectively, with significant difference (P <0.05). The risk of abnormal bone tissue in Pp / PP group was higher than that in Pp / PP group (PR = 1.087, 95% CI = 1.053-1.437 or PR = 1.145, 95% CI = 1.104-1.318). Conclusion: Carrying ERαPvuⅡPp / PP genotype may increase the sensitivity of bone tissue to fluoride exposure.