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目的比较血液灌流串联血液透析治疗药物中毒与常规保守方法治疗药物中毒的救治效果。方法将2005年1月—2010年10月收治的104例急性药物中毒患者分为对照组、血液灌流串联血液透析治疗组(HDP组)两组,分别进行常规保守治疗和保守治疗加血液净化治疗,观察两组患者的昏迷时间、平均住院天数、治愈率、死亡率。结果 HDP组与对照组比较,昏迷时间、住院时间明显缩短,死亡率明显下降,经统计学检验有显著性差异(P<0.05),治愈率明显提高(P<0.05)。结论血液灌流串联血液透析救治急性药物中毒效果明显优于对照组,抢救成功率高、住院时间短、死亡率低,是值得推广的方法。
Objective To compare the therapeutic effects of hemoperfusion with hemodialysis in treating drug poisoning and conventional conservative treatment of drug poisoning. Methods One hundred and four patients with acute drug poisoning admitted from January 2005 to October 2010 were divided into two groups: control group, hemodialysis group (HDP group), routine conservative treatment and conservative treatment plus blood purification treatment The coma time, average days of hospitalization, cure rate and mortality of two groups were observed. Results Compared with the control group, the coma time and hospitalization time were significantly shortened and the mortality rate was significantly decreased in HDP group (P <0.05). The cure rate was significantly increased (P <0.05). Conclusions Hemoperfusion in series hemodialysis is more effective than the control group in the treatment of acute drug poisoning. The success rate of rescue is high, the hospitalization time is short and the mortality rate is low, which is worth to be popularized.