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目的:探讨血清降钙素原(PCT)作为早期诊断新生儿败血症指标的临床价值。方法:应用免疫色谱法对101例新生儿进行PCT水平测定,并与C反应蛋白(CRP)作比较。将患儿按出院诊断分为败血症组、一般感染组、非感染组进行分析。结果:败血症组患儿血清PCT和CRP明显高于一般感染组和非感染组,差异有统计学意义(P<0.05);一般感染组与非感染组血清PCT、CRP比较差异有统计学意义(P<0.05)。以0.5ng/mL为临界值,PCT诊断新生儿败血症的敏感度为92.11%,特异度为78.79%;以8.0mg/L为临界值,诊断败血症的敏感度为65.79%,特异度为69.70%。与CRP相比,PCT诊断败血症的敏感性、特异性更高。经有效抗生素治疗后,血清PCT下降幅度明显大于血清CRP下降幅度。结论:新生儿血清中PCT水平的检测对败血症的早期诊断及病情程度判断、治疗效果的评价具有重要价值。
Objective: To investigate the clinical value of serum procalcitonin (PCT) as an index for early diagnosis of neonatal sepsis. Methods: The levels of PCT in 101 newborns were determined by immunochromatography and compared with C-reactive protein (CRP). According to the diagnosis of discharged children were divided into sepsis group, general infection group, non-infected group analysis. Results: Serum PCT and CRP in sepsis group were significantly higher than those in normal and non-infected group (P <0.05). There was significant difference in serum PCT and CRP between sepsis group and non-infected group P <0.05). The sensitivity and specificity of PCT to diagnose neonatal septicemia were 92.11% and 78.79% respectively at the threshold of 0.5ng / mL. The sensitivity and specificity of PCT in diagnosing sepsis were 65.79% and 8.09% . Compared with CRP, PCT diagnosis of sepsis is more sensitive and specific. After effective antibiotic treatment, serum PCT decreased significantly more than serum CRP decline. Conclusion: The detection of PCT levels in neonatal serum is of great value in the early diagnosis of sepsis and judgment of the severity of disease, and in the evaluation of the therapeutic effect.