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目的:观察超敏C反应蛋白(hs-CRP)与冠心病慢性心力衰竭患者预后指标的关系。方法:回顾性收集年龄50～75岁,氨基末端B型利钠肽前体(NT-proBNP)≥300ng/L的冠心病慢性心力衰竭患者111例,记录NYHA心功能分级、血液学、心脏彩色多普勒超声检查结果。分别以左室射血分数(LVEF)40%、肾小球滤过率(GFR)90ml/min、血红蛋白(Hb)115g/L、NT-proBNP900ng/L为切点将患者分为若亚干组,观察hs-CRP水平的差异。结果:NT-proBNP≥900ng/L亚组患者hs-CRP高于NT-proBNP<900ng/L亚组,差异有统计学意义(P<0.05),合并肾功能不全亚组患者hs-CRP高于未合并肾功能不全亚组患者,差异有统计学意义(P<0.05)。研究中未发现hs-CRP在不同NYHA心功能分级、舒张和收缩功能不全、贫血患者存在差异(P>0.05)。结论:hs-CRP与冠心病慢性心力衰竭患者NT-proBNP、肾功能有关,但作为诊断和预后指标尚待进一步循证医学证据。
Objective: To investigate the relationship between hs-CRP and prognosis in patients with chronic heart failure of coronary heart disease. Methods: A total of 111 CHD patients aged 50-75 years with NT-proBNP ≥ 300 ng / L were enrolled in this study. NYHA functional class, hematology, heart color Doppler ultrasound examination results. Patients were divided into three groups according to LVEF (40%), glomerular filtration rate (GFR) 90ml / min, hemoglobin 115g / L and NT-proBNP 900ng / , Observe the difference of hs-CRP level. Results: The hs-CRP in NT-proBNP≥900ng / L subgroup was significantly higher than that in NT-proBNP <900ng / L subgroup (P <0.05). The hs-CRP in subgroup with renal insufficiency was higher than that in NT- In the subgroup of patients without renal dysfunction, the difference was statistically significant (P <0.05). The study found no hs-CRP in different NYHA cardiac function classification, diastolic and systolic dysfunction, anemia patients were different (P> 0.05). Conclusion: hs-CRP is associated with NT-proBNP and renal function in CHD patients with chronic heart failure. However, further evidence-based medical evidence is needed as a diagnostic and prognostic indicator.