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目的探讨脑泰方对脑缺血再灌注沙鼠脑组织谷氨酸及其转运体功能的影响。方法 :采用沙土鼠双侧颈总动脉阻断模型。利用脑组织突触膜颗粒对3H L 谷氨酸摄入量及高效液相色谱仪观察脑泰方对脑组织谷氨酸含量的影响。结果 :模型组脑组织谷氨酸含量明显高于假手术组 (P <0 0 1) ,而其转运体功能则明显低于假手术组 (P <0 0 1) ;脑泰方治疗组能明显降低脑组织谷氨酸含量 (P <0 0 1)及显著升高大脑皮层、海马、纹状体谷氨酸转运体功能 (P <0 0 1)。结论 :脑泰方对缺血脑组织的保护作用是通过提高谷氨酸转运体功能以降低神经元突触中过多堆积的谷氨酸 ,从而减轻其兴奋性毒性
Objective To investigate the effect of Naotaifang on the function of glutamate and its symporter in brain tissue of gerbils after cerebral ischemia-reperfusion. Methods: The models of bilateral common carotid artery occlusion in gerbils were used. The effect of Naotaifang on glutamate content in brain tissue was observed by using 3H L glutamate intake and brain tissue synaptic membrane particles. Results: The content of glutamate in brain tissue of the model group was significantly higher than that of the sham group (P < 0.01), but the transporter function was significantly lower than that of the sham group (P <0 01); The glutamate content in brain tissue was significantly decreased (P < 0 01) and the glutamate transporter function in cerebral cortex, hippocampus and striatum was significantly increased (P <0 01). Conclusion : The protective effect of Naotaifang on ischemic brain tissue is to reduce glutamate in synapses by increasing the function of glutamate transporter, thereby reducing its excitotoxicity.