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目的本文旨在探讨徐州地区女性宫颈细胞中人乳头瘤病毒(HPV)感染基因谱的分布情况及其临床意义。方法从8 010份徐州地区宫颈细胞标本中提取23种HPV DNA,使用聚合酶链式反应和反向点杂交相结合的基因芯片技术对宫颈细胞23种HPV型别进行测定,同时分析受检者的相关资料。结果 8 010例女性中有1 852例HPV感染者,总的HPV感染率为23.12%,其阳性检出率一重型别为17.17%,一重中最主要感染型别是HPV16型为4.35%,其次为HPV58型2.12%、52型1.82%。阳性检出率多重HPV感染为5.96%;其中16+58型、16+52型、11+16型,分别占多重感染的4.40%、2.94%和2.52%,是多重感染的主要型别。结论一重HPV16、58和52型及多重16+58、16+52和11+16型是感染徐州地区女性宫颈细胞的主要基因型,此基因芯片检测技术适用于宫颈细胞标本,一次可检测23种HPV基因型,其特异性强,敏感性高,对我国女性宫颈HPV感染基因型分布的分子流行病学调查研究具有重要的意义。
Objective This article aims to investigate the distribution of human papillomavirus (HPV) gene in female cervical cells in Xuzhou and its clinical significance. Methods Totally 23 types of HPV DNA were extracted from 8 010 cervical samples collected from Xuzhou area. 23 HPV types of cervical cells were determined by polymerase chain reaction and reverse dot blot hybridization. Meanwhile, Related information. Results Among 8 010 women, there were 1 852 cases of HPV infection. The total HPV infection rate was 23.12%. The positive rate of HPV infection was 17.17%. The most common infection type was HPV-1 4.35% HPV58 type 2.12%, 52 type 1.82%. The positive detection rate of multiple HPV infection was 5.96%, of which 16 + 58, 16 + 52 and 11 + 16 accounted for 4.40%, 2.94% and 2.52% of the multiple infections respectively, which were the main types of multiple infections. Conclusion The results showed that HPV16, HPV58, HPV58 and 52 and multiple types 16 +58, 16 +52 and 11 +16 were the major genotypes of female cervical cells infected in Xuzhou. The gene chip detection technique was suitable for cervical cell samples, HPV genotype, its specificity is high and its sensitivity is high. It is of great significance to investigate the molecular epidemiology of HPV genotype distribution in Chinese women.