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测定反复呼吸道感染（RRTI）患儿外周血单个核细胞（PBMC）中T细胞亚群、T细胞增殖、T细胞活化及未活化时［Ca2+］的变化。结果RRTI患儿CD4；细胞比例降低，CD8细胞增高，CD4／CD8比值下降，与对照组相比，均有极显著性差异（P＜0．01）。T细胞增殖低于对照组（P＜0．01）。当T细胞活化时RRTI组［Ca2+」明显低于对照组。提示RRTI患儿存在T细胞亚群比例失衡，T细胞增殖能力降低，T细胞活化过程中的［Ca2+」动员存在一定的程度异常，是其增殖能力降低的原因之一。
To determine the changes of T cell subsets, T cell proliferation, T cell activation and [Ca2 +] in non-activated peripheral blood mononuclear cells (PBMC) in children with recurrent respiratory tract infection (RRTI). Results Compared with the control group, the percentage of CD4 in the RRTI children decreased, the percentage of CD8 cells increased, and the ratio of CD4 / CD8 decreased in the RRTI group (P <0.01). T cell proliferation was lower than the control group (P <0.01). When T cell activation RRTI group [Ca2 +] was significantly lower than the control group. It is suggested that there is an imbalance of T lymphocyte subsets and a decreased ability of T cell proliferation in RRTI children, and the degree of abnormality of [Ca2 +] mobilization during T cell activation is one of the reasons for the decrease of proliferative ability.