局限性尿道淀粉样变是罕见的疾病。本文收集了文献报告的11例,作者又报告了另外2例,其表现类似于尿道肿瘤。病例摘要如下: 例1 50岁,男性,主诉阴茎肿物,合并有尿道血性溢液和尿流不畅。体检发现拇指大,硬而表面不规则的悬垂部尿道肿块。逆行尿道造影在前尿道相当于触及肿物处呈光滑的狭窄。行切开肿物活检,其冰冻切片仅显示无定型结构而无癌组织。行包括邻边的尿道组织在内的肿块的局部切除(Johanson一期手术)。切除标本为淡黄色的坚硬肿块,切面不规则。用刚果红染色等各种不同的组织学检查作出最后的诊 Limitations Urethral amyloidosis is a rare disease. This article collected 11 cases reported in the literature, the authors reported another two cases, its performance is similar to urethral tumors. Case summary is as follows: Example 1 50-year-old male, complained of penile tumor with urethral bloody discharge and poor urinary flow. Physical examination found thumbs, hard and irregular surface overhang urethral mass. Retrograde urethrography in the anterior urethra is equivalent to touch the tumor was smooth stenosis. Line incision biopsy, the frozen section shows only amorphous structure without cancer. Local excision of lumps including adjacent urethral tissue (Johanson stage I surgery). Excised specimens for the light yellow hard lumps, irregular section. The final diagnosis was made using various histological examinations such as Congo red staining